The Indianapolis Colts regular season is underway, and this schedule is your guide to when and where future games will be played and who the Colts will play, as well as the final scores of games played to date.
The Colts' 2009 Regular Season Games
| Date | Opponent | Home/Away | Won/Lost | Score |
| 9-13-09 | Jacksonville Jaguars | Home | Won | 14-12 |
| 9-21-09 | Miami Dolphins | Away | Won | 27-23 |
| 9-27-09 | Arizona Cardinals | Away | Won | 31-10 |
| 10-4-09 | Seattle Seahawks | Home | Won | 34-17 |
| 10-11-09 | Tennessee Titans | Away | Won | 31-9 |
| 10-18-09 | Bye | |||
| 10-25-09 | St. Louis Rams | Away | Won | 42-6 |
| 11-1-09 | San Francisco 49ers | Home | Won | 18-14 |
| 11-8-09 | Houston Texans | Home | Won | 20-17 |
| 11-15-09 | New England Patriots | Home | Won | 35-34 |
| 11-22-09 | Baltimore Ravens | Away | ||
| 11/29/09 | Houston Texans | Away | ||
| 12-6-09 | Tennessee Titans | Home | ||
| 12-13-09 | Denver Broncos | Home | ||
| 12-17-09 | Jacksonville Jaguars | Away | ||
| 12-27-09 | New York Jets | Home | ||
| 1-3-10 | Buffalo Bills | Away |
